Abstract
This paper describes the method for obtaining a new derivative of the closo-decaborate anion with diethylenetriaminepentaacetic acid (DTPA) as a pendant group attached to the boron cluster through an alkoxyl spacer chain. This derivative is formed by the interaction of 1,4-dioxane derivative of the anion [B10H10]2- with DTPA potassium salt in an aqueous medium. As a result of the reaction, an exo-polyhedral cyclic substituent is opened, and then the addition of a polyfunctional group through an oxygen atom occurs. The synthesized compound is in fact an effective polydentate ligand capable of coordinating to the complexing agent both due to the donor atoms of the attached DTPA fragment and through the formation of three-center two-electron bonds. The obtained compound interacts with gadolinium(III) carbonate forming a complex of the composition [Gd2B10H9O2C4H8(dtpa)]·3H2O. The synthesized substances were studied by IR spectroscopy, polynuclear (11B, 13C and 1H) NMR spectroscopy, ESI mass spectrometry, elemental and thermographic analysis. closo-Decaborate with the pendant DTPA group is of interest in 10B neutron capture therapy of malignant tumors due to the high content of boron atoms and a convenient way of their transport to the affected cells. The obtained boron-containing derivatives of gadolinium(III) can act as drugs of combined action, because they can perform, in addition to the above described therapeutic function, the diagnostic function due to the presence of gadolinium atoms int hem.
Highlights
This paper describes the method for obtaining a new derivative of the closo-decaborate anion with diethylenetriaminepentaacetic acid (DTPA) as a pendant group attached to the boron cluster through an alkoxyl spacer chain
DTPA (Aldrich), хлорид алюминия (99.9%, Aldrich), 1,4-диоксан, карбонат гадолиния(III) тригидрат, гидроксид калия, этанол (95%), ацетонитрил, сульфат натрия безводный отечественного производства
По данным физико-химических методов анализа, катион гадолиния(III) связывает лиганд посредством атомов азота и кислорода пендантной группы
Summary
Метод получения производного клозо-декаборатного аниона с пендантной DTPA-группой Как следует из литературных данных, для координации катионов гадолиния(III) широко применяются различные композиции диэтилентриаминпентауксусной кислоты (DTPA) [17]. Целью работы является получение нового производного аниона [B10H10]2– с присоединенной пендантной группой по реакции 1,4-диоксанового производного клозо-декаборатного аниона ([B10H9O2C4H8]–) с DTPA. После этого к сухому порошку добавляли 0.55 г (9.8 ммоль) КОН и 15 мл воды, и образовавшийся раствор выдерживали при 40 °С в течение 2 ч, после чего упаривали на роторном испарителе до маслообразного состояния.
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