Abstract
The paper describes a newmethod of Information Structure Analysis (ISAN) for protein sequences. The method uses a new approximation for description of protein sequences, which allows us to detect hierarchically organized elements (Information Structure Elements (ISEL)) in them. It is shown that elements of the higher hierarchy level of information structure correspond to stable elements in the spatial structure of globular proteins. Based on the ISAN method, we propose an approach to design of the new sequences of recombinant proteins. The proposed approach was confirmed experimentally in the case of obtaining functionally active recombinant proteins.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
