The methanolysis kinetics and dissociation constants of 1-(subst. benzoyl)-3-phenylthioureas

Abstract

A series of seven 1-(subst. benzoyl)-3-phenylthioureas have been prepared and their dissociation constants and solvolysis rate constants have been measured in methanol at 25 °C. The reaction constants found show that the solvolysis rate is limited by the attack of methoxide ion on the benzoyl carbonyl group of the non-dissociated substrate. The polar effect of substituents in benzoyl group is extensively transferred also by the intramolecular hydrogen bond.