Abstract
Abstract α-Phenyl-α-(2-pyridyl) thioacetamide (SC 15396; antigastrin) is metabolized by the supernatant fraction of rat liver homogenate to give two metabolites. The major metabolite has been identified as α-phenyl-α-(2-pyridyl)acetonitrile. Three other thioamides, analogues of SC 15396 also give the corresponding nitriles in these conditions.
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