The metabolism of thalidomide: the spontaneous hydrolysis of thalidomide in solution.

Abstract

British Journal of Pharmacology and ChemotherapyVolume 25, Issue 2 p. 324-337 Free Access THE METABOLISM OF THALIDOMIDE: THE SPONTANEOUS HYDROLYSIS OF THALIDOMIDE IN SOLUTION H. SCHUMACHER, H. SCHUMACHER Department of Biochemistry, St. Mary's Hospital Medical School, London, W.2Search for more papers by this authorR. L. SMITH, R. L. SMITH Department of Biochemistry, St. Mary's Hospital Medical School, London, W.2Search for more papers by this authorR. T. WILLIAMS, R. T. WILLIAMS Department of Biochemistry, St. Mary's Hospital Medical School, London, W.2Search for more papers by this author H. SCHUMACHER, H. SCHUMACHER Department of Biochemistry, St. Mary's Hospital Medical School, London, W.2Search for more papers by this authorR. L. SMITH, R. L. SMITH Department of Biochemistry, St. Mary's Hospital Medical School, London, W.2Search for more papers by this authorR. T. WILLIAMS, R. T. WILLIAMS Department of Biochemistry, St. Mary's Hospital Medical School, London, W.2Search for more papers by this author First published: October 1965 https://doi.org/10.1111/j.1476-5381.1965.tb02053.xCitations: 60AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat REFERENCES Beckmann, R. (1962). Über das Verhalten von Thalidomid im Organismus. Arzneimittel-Forsch., 12, 1095– 1098. Beckmann, R. & Kampf, H. H. (1961). Zur quantitativen Bestimmung und zum qualitativen Nachweis von N-Phthalylglutaminsäure-imid (Thalidomid). Arzneimittel-Forsch., 11, 45– 47. Green, J. N. & Benson, B. C. (1961). The spectrophotometric determination of thalidomide in body fluids. J. Pharm. Pharmacol., 13, 117– 121T. King, F. E., Jackson, B. S. & Kidd, D. A. A. (1951). Syntheses from phthalimido-acids. Part II. Further reactions of phthalylglutamic anhydride. J. chem. Soc., 243– 246. King, F. E. & Kidd, D. A. A. (1949). A new synthesis of glutamine and of γ-dipeptides of glutamic acid from phthalylated intermediates. J. chem. Soc., 3315– 3319. Schumacher, H., Smith, R. L. & Williams, R. T. (1965). The metabolism of thalidomide: the fate of thalidomide and some of its hydrolysis products in various species. Brit. J. Pharmacol., 25, 338– 351. Sondheimer, E. & Holley, R. W. (1957). Imides from asparagine and glutamine, II. α-Aminoglutarimide. J. amer. chem. Soc., 79, 3767– 3770. Citing Literature Volume25, Issue2October 1965Pages 324-337 ReferencesRelatedInformation