Abstract
The metabolism of sodium amylopectin sulfate (SN-263) has been studied in adult rats, 14C and 35S-labeled preparations being used. Previous studies have shown that this pepsin inhibitor is an effective antiulcer compound in experimental animals and in man. In the present study, the major fraction of the drug was excreted in the feces and exhibited a biological half-life of about 24 hours. A small amount of 35S appeared in the urine primarily as inorganic sulfate. It is concluded that the 35S that appeared in the urine was due not to absorption of the intact SN-263 molecule but to absorption of inorganic sulfate released by bacterial sulfatase activity in the large intestine. The 14C-labeled drug was excreted only in the feces; negligible amounts of 14C were detected in the urine or expired air. The compound was also found not to be absorbed in rats in which gastric ulcers had been induced by cortisol treatment.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
