Abstract
The Metabolism of Neoplastic Tissues: The Relative Rates of Acetate and Pyruvate Utilization by Surviving Tissue Slices of Mouse Tumours
Highlights
Earlier studies of these reactions in slices of tumour tissues to which acetate-_-C'4 was added as a substrate did not reveal significant features in the metabolic rates common to each of the tumours belonging to one of three different groups studied (Emmelot and Bosch, 1955a, 1955b)
The absolute rates of pyruvate and acetate utilization differ significantly, the ratio between pyruvate and acetate incorporation into cholesterol is approximately constant for both hepatomas
The results showed that the content of this enzyme paralleled roughly the synthetic abilities of the tumours, it was demonstrated that, in general, the level of coenzyme A (CoA) need not be the rate limiting factor in biosynthesis
Summary
Earlier studies of these reactions in slices of tumour tissues to which acetate-_-C'4 was added as a substrate did not reveal significant features in the metabolic rates common to each of the tumours belonging to one of three different groups studied (Emmelot and Bosch, 1955a, 1955b). TABLE II.-The in vitro Incorporation of Tracer from Acetate-I-C'4 and Pyruvate2-C14 into Respiratory Carbon Dioxide, Proteins, Cholesterol and Long-chain
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
