Abstract
The urinary metabolites of ethylcyclohexane (ECH) in male Fischer 344 rats, administered the hydrocarbon by gavage, included 4-ethylcyclohexanol, 2-hydroxy-4-ethylcyclohexanone, 2 c-hydroxy-4 c-ethylcyclohexanol, 2 c-hydroxy-4 t-ethylcyclohexanol, 2 t-hydroxy-4 c-ethylcyclohexanol and 2 t-hydroxy-4- t-ethylcyclohexanol. The metabolites were identified using gasliquid partition chromatography (GC) and gas-liquid partition chromatography/mass spectrometry (GC/MS). Metabolism of ECH occurred exclusively on the ring. Histopathologic examination revealed mild to moderate renal damage.
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