Abstract
Dihydrochlordene has been shown to be converted into hydroxylated derivatives by housefly and pig liver microsomes, fortified with NADPH 2. The products were characterised, as both free hydroxyl-compounds and their trimethylsilyl ethers, by chromatographic comparison with authentic compounds. The metabolism of authentic hydroxydihydrochlordenes by these microsomal systems provided further evidence for the structures assigned to primary metabolites. The inhibition by sesamex of dihydrochlordene hydroxylation by microsomal enzymes explains the synergistic effect of sesamex with this toxicant in vivo in houseflies but the low order of the effect indicates that dihydrochlordene has a low intrinsic toxicity.
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