Abstract
Choline chloride, administered intragastrically to normal rats (200 mg./kg. body weight) gave rise to urinary total trimethylamines (TTMA) in yields of 10–66.2% of the administered dose. However, germfree rats given the same dose of choline chloride excreted an average of only 0.6% of the choline as TTMA. Feeding of choline chloride to conventional rats on four successive days gave rise to a daily TTMA excretion comparable with those fed only once; germfree rats fed this way, excreted only a trace of TTMA on any of the 4 days. Neither the conventional nor the germfree rats excreted more than a trace of choline in the urine under any conditions, nor was urinary creatinine affected by choline feeding. On the other hand, ingested trimethylamine was quantitatively excreted by both groups. Tracer studies carried out with methyl-labeled choline-C 14, showed that labeled urinary TTMA was excreted only when large doses of unlabeled choline were fed with the tracer. The conclusion is drawn that the formation of urinary trimethylamine from choline is brought about by microbial enzymes.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
