Abstract
3-Methylheptane (3-MH), a component of fuels and solvents, is found widely distributed in the environment. Male 344 Fischer rats, dosed by gavage with 3-MH yielded the following urinary metabolites, identified by gas chromatography and mass spectrometry: 3,5-diethyl-2,3-dihydrofuran, 3-ethyl-6-methyl-2,3-dihydropyran, 3-methyl-heptanol, 3-methyl-2-heptanol, 5-methyl-2-heptanol, 2-n-butyl-1,3-butanediol, 2-ethyl-1,3-hexanediol, β-methyl-δ-enantholactone, 3-methyl-3,4-heptanediol, 3-methyl-3,4-heptanediol, 3-methyl-3,5-heptanediol, 2-ethyl-1,4-hexanediol, δ-methyl-δ-enantholactone, 5-methyl-2,5-heptanediol, 2-ethyl-1,5-hexanediol and 2-ethylhexanoic acid. Pathological evaluation of the proximal tubules of the rat's kidneys rated 3-MH as a moderate inducer of the the hyaline droplet nephropathy induced by branched chain hydrocarbons.
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