Abstract
The excretion of radioactivity in the urine of four women, after oral administration of tritiated 17α-ethynyl-estr-5(10)-ene-3-one-17β-o1 (norethynodrel) averaged 38 per cent of the administered dose. Two women receiving oral doses of tritiated 17α-ethynyl-19-nortestosterone (norethindrone) excreted, respectively, 70 and 50 per cent of the dose in their urine, 30 per cent of the dose of 3H-norethynodrel was found in bile collected from one subject. Thirty to sixty per cent of the radioactivity in the urine of subjects receiving either 3H-norethynodrel or 3H-norethindrone was conjugated as glucosiduronate and another 9 to 25 per cent was another conjugate, presumably sulfate. Some evidence was obtained on the nature of the conversion products of norethynodrel in the glucosiduronate fraction of the urine of two women. These were mainly steroid alcohols, all but one of which carried the ethynyl side chain. Only traces of ketosteroids were present, and no evidence was found of major conversion of norethynodrel to phenolic compounds.
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