The Meta-analysis of immunogenicity of meningococcal ACYW135 polysaccharide tetanus toxoid conjugate vaccine

Abstract

Objective To evaluate the immunogenicity of meningococcal ACYW135 polysaccharide tetanus toxoid conjugate vaccine (MPCV-ACYW135-TT). Methods Searching random control trials (RCT) in National Center for Biotechnology Information (NCBI) , Cochrane Library (CL) , China Biology Medicine disc (CBMd) , China National Knowledge Infrastructure (CNKI) and Wanfang Database for comparing immunogenicity of MPCV-ACYW135-TT. The positive response rate (PRR) and geometric mean titer (GMT) of serum bactericidal activity (SBA) antibody with an interval of one month after vaccination were used as our endpoints. We pooled risk difference (RD) or standardized mean difference (SMD) of PRR and GMT from both treatment and control groups in different studies. Meta -analysis was made by RevMan5.1 software. Results Thirteen studies were included, of which 9 studies compared MPCV-ACYW135-TT with meningococcal ACYW135 polysaccharide vaccine (MPV-ACYW135) and 4 studies compared the immunogenicity of MPCV-ACYW135-TT with meningococcal C polysaccharide cross reactive material 197 conjugate vaccine (MPCV-C-CMR197). Compared with MPV-ACYW135, the RDs of PRR of antibodies against four serogroups A, C, Y and W135 after immunization with MPV-ACYW135-TT were from 0.03 to 1.15; the SMDs of GMT of antibodies against three serogroups A, Y and W135 were from 0.33 to 1.22. The SMDs of GMT of the antibody against serogroup C showed no significant difference between children aged 1-2 years old vaccinated with MPV-ACYW135-TT and MPCV-C-CMR197 (P>0.05). Conclusions It suggests that the MPCV-ACYW135-TT vaccine is as immunogenic as the other commercial available meningococcal vaccines. Key words: Meningitis; Meningococcal; Meningococcal ACYW135 polysaccharide tetanus toxoids conjugate vaccine; Immunogenicity; Meta analysis