Abstract
The cellular actin cortex is a thin meshwork of filamentous (F)-actin and nonmuscle myosin II that lies immediately beneath the cell membrane. The cortex exhibits fluid-like properties in that it can undergo rapid and dramatic changes in shape during cell protrusion generation and migration. At the same time, the cortex must remain stably linked to the cell membrane to protect the membrane from mechanical disruption. How these two seemingly opposed functions are achieved at the molecular level is unclear.
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