Abstract
Tyrosinase from different sources has different characteristics (1); that obtained from plant tissue can usually be prepared in colloidal solution, while that obtained from mammalian tissue is held by ultramicroscopic, cytoplasmic particles. Localization of tyrosinase activity in suspensions of cell particles was first reported by Herrmann and Boss (2) in preparations of the ciliary body of the bovine eye. Later, Lerner et al. (3) also reported that in their differential-centrifugation studies of suspensions of homogenized Harding-Passey mouse melanoma, tyrosinase activity was found to be present in the particulate fraction. They conjectured that the structural elements in this fraction were “microsomes, or particles the size of microsomes, which were formerly part of larger aggregates that were dispersed during the experiments.
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