Abstract
THE CONCEPTION that treatment of Graves' disease (1) is primarily surgical, is widespread despite the fact that American as well as European literature contains numerous reports of satisfactory results with non-surgical treatment in selected cases. It is undoubtedly true that since Plummer and Boothby (2, 3, 4) inaugurated routine preoperative iodine preparation, the prognosis of surgical procedures in Graves' disease has been markedly improved. It is also true that a high percentage of cures is obtained by subtotal thyroidectomy, but the results are by no means universal. Because of these operative failures, and because of those cases not amenable to surgery, it is the immediate concern of the internist, from a practical point of view, to continue his search for a satisfactory medical treatment. The mode of action of different types of therapy is still far too speculative to be discussed in this purely clinical paper, but one must admit that it is extremely difficult for patho-physiologists to comprehend...
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