Abstract

The typical serological feature of chronic HBV infection is the presence of circulating HBsAg in patients and lack of anti-HBs.However,the co-existence of HBsAg and anti-HBs in patients with chronic HBV infection has been reported more and more.So far,the mechanism underlying the presence of both HBsAg and anti-HBs remains unknown.This review focuses on the possible mechanisms leading to this phenomenon. Key words: Hepatitis B virus; Hepatitis B virus surface antigens; Anti-HBs; Co-existence

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