Abstract
Systemic (intravenous) thrombolysis with recombinant tissue plasminogen activator (rt-PA) is a proved effective treatment modality in a certain group of patients with ischemic stroke (IS) in the first 4.5 hours after the onset of neurological symptoms. The main mechanism for improving functional outcomes in patients treated with intravenous thrombolysis is reperfusion of an ischemic brain portion. The results of intravenous thrombolytic therapy are shown in 60 IS patients (18 women and 42 men; mean age 61 years). Different mechanisms of reperfusion during systemic thrombolysis, which are not confined to thrombus- or embolus-occluded artery recanalization, but are a portrait of the systemic effect of the thrombolytic drug and include collateral blood flow activation, gradual recanalization, etc.
Highlights
Systemic thrombolysis with recombinant tissue plasminogen activator is a proved effective treatment modality in a certain group of patients with ischemic stroke (IS) in the first 4.5 hours after the onset of neurological symptoms
The main mechanism for improving functional outcomes in patients treated with intravenous thrombolysis is reperfusion of an ischemic brain portion
The results of intravenous thrombolytic therapy are shown in 60 IS patients (18 women and 42 men; mean age 61 years)
Summary
Рис. 2. КТ-перфузия. Реперфузия теменно-затылочной области правого полушария на фоне тромболитической терапии. а – область без перфузии в правом полушарии большого мозга, окруженная зоной снижения перфузии; б – исчезновение областей без перфузии или ее снижения сразу после тромболизиса тромболитической терапии составляет 43–71% [16], при этом показатель полного восстановления кровотока убывает в ряду: внутриартериальный тромболизис плюс механическая экстракция тромба, комбинация внутривенного и внутриартериального тромболизиса, внутриартериальный тромболизис, внутривенный тромболизис [16]. И хотя частота реканали-
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