Abstract
Reovirus is concentrated in lysosomes soon after penetrating L cells. Hydrolases contained within the lysosomal compartment digest the outer layer of viral capsomeres but do not degrade the viral core proteins which form the subviral particle (SVP). Parental SVPs have been recovered from reovirus-infected cells. These SVPs are similar, but not identical, in morphology and protein composition to SVPs produced in vitro by chymotrypsin digestion of intact virus. Moreover, they catalyze the synthesis of ssRNA molecules which hybridize specifically with all ten segments of the double-stranded viral genome.
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