Abstract

339 It is well known that synaptic transmission is the main neuronal interaction mechanism representing a specialized chemical signaling. The interaction of two neurons can be regulated at the preand postsynaptic levels. Using the electron microscopic immunocytochemistry it was shown that the axons making synapses on the vertebrate motoneurons are contacted not only by GABAergic, but also by glutamateand glycine-containing terminals. It testifies that multiple neurotransmitters can be used for presynaptic regulation of synaptic transmission. This statement is confirmed by postsynaptic potential and current modifications after membrane receptor agonist and antagonisat application. The co-release of different transmitters and postsynaptic effect interactions are considered as possible mechanisms of synaptic transmission regulation.

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