Abstract
Diminished ovarian reserve (DOR) is the weakening of ovarian oocyte production and quality. It will further become premature ovarian failure without timely cure. However, disease pathology and diagnostic markers are still incompletely understood. Liu-Wei-Di-Huang (LWDH) pill, a traditional Chinese medicine formula, is commonly used in the treatment of DOR in China. To explore the mechanism of the effect of LWDH on in vitro fertilization (IVF) outcomes in patients with DOR, a pseudotargeted metabolomics study combined with multivariate data processing strategy was carried out. A liquid chromatography tandem mass spectrometry-based metabolomics approach was applied to characterize metabolic biomarker candidates. Multiple pattern recognition was used to determine groups and confirm important variables. A total of 21 potential biomarkers were characterized, and related metabolic pathways were identified. The study displayed that the established pseudotargeted metabolomics strategy is a powerful approach for investigating the mechanism of DOR and LWDH. In addition, the approach may highlight biomarkers and metabolic pathways and can capture subtle metabolite changes from headache, which may lead to an improved mechanism understanding of DOR diseases and LWDH treatment.
Highlights
Diminished ovarian reserve (DOR) is often found in the process of long-term infertility seeking assisted pregnancy, which affects female sex hormone levels and fertility [1]
3.2 kg of prepared radix rehmanniae, 1.6 kg of prepared rhizoma dioscoreae, 1.6 kg of prepared fructus corni, 1.2 kg of prepared tuckahoe, 1.2 kg of prepared rhizoma alismatis, and 1.2 kg of prepared tree peony bark were crushed by pulverizer. en, the refine honey was added to the herbal powder at a ratio of 3 to 10. ey were kneaded for half an hour and prepared into LWDH pills with a mold
Syndrome Integral. e total syndrome integral of DOR patients decreased significantly after treatment using LWDH pill (p < 0.001). e syndrome including YaoXiSuanRuan, WuXinFanRe, KouGanYanZao, dizziness, emaciation, and forgetfulness was significantly improved after treatment (p < 0.05)
Summary
Diminished ovarian reserve (DOR) is often found in the process of long-term infertility seeking assisted pregnancy, which affects female sex hormone levels and fertility [1]. Ovarian reserve has become an important factor affecting the outcome of assisted reproductive technology (ART). Liu-Wei-Di-Huang (LWDH) pill is a traditional Chinese medicine (TCM) formula for the treatment of DOR, with high efficiency and low toxicity in China [3]. It provides a good clinical effect in restoring menstrual cycle, protecting ovarian function in advance, and improving ART outcomes [4]. Xia and Wang improved ovarian function in patients with DOR by reestablishing yin-yang balance of heart-kidney-uterus axis and restoring normal reproductive endocrine using LWDH [5].
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