Abstract
The mechanisms and benefits of exercise At Wayne State University, Robert Wessells and his team are making significant strides in identifying potential exercise mediators or mimetics that could help mitigate pathologies resulting from prolonged sedentary periods. Exercise is an indispensable part of our daily life to maintain a healthy body and brain across ages. Regular exercise has been shown to reduce the incidence of many age-related diseases and preserves healthy function during normal aging, improving quality of life and independence. However, chronic exercise remains inaccessible to portions of the population due to injury, illness, advanced age or job-enforced sedentary periods. Therefore, identifying potential exercise mediators or mimetics that can deliver the benefits of exercise to sedentary people would be potentially transformative in reducing disease burden worldwide. At Wayne State University in Detroit, Michigan, USA, Dr Robert (RJ) Wessells and his lab team have used the many genetic tools available for use in fruit flies to identify several single molecules that act as powerful exercise mimetics in the brain and muscle of sedentary flies.
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