The mechanism of treating chronic bronchitis by Fritillaria thunbergii was discussed based on network pharmacology

Abstract

Objective: The mechanism of treating chronic bronchitis by Fritillaria thunbergii was studied by network pharmacology. Methods: The targets of active chemical components in Fritillaria thunbergii were predicted, the component-target-disease network was constructed, and the topological parameters of the network were analyzed; meanwhile, protein interaction network (PPI) was constructed, and gene GO functional annotation and KEGG pathway enrichment were analyzed. Results: There are 6 active ingredients and 44 potential targets of Fritillaria thunbergiiin the treatment of chronic bronchitis, the HRAS PIK3CA, CCND1, CDK2, AKT1, MTOR, known targets such as Fritillaria thunbergii may be important targets for the treatment of chronic bronchitis. The treatment of chronic bronchitis by Fritillaria thunbergii mainly involves the biological processes such as peptidyl serine phosphorylation, platelet activation, protein C terminal binding insulin binding, exogenous transport atpase activity, histone kinase activity and so on, major signaling pathways include prostate cancer, melanoma, estrogen signaling pathway, pi3k-akt signaling pathway, etc. Conclusions: This study preliminarily revealed the molecular mechanism of Fritillaria thunbergiiin the treatment of chronic bronchitis, laying a foundation for further experimental study on the basis of pharmacodynamic substances and mechanism of action.