Abstract
Exposure of cerebellar granule neurons in culture to the inhibitor of the plasma membrane Na+/H+ exchanger 5-(N-ethyl-N-isopropyl)-amiloride (EIPA) for 24 h resulted in intense death of neurons. Menadione and the antioxidant trolox prevented the neurocytotoxic effect of EIPA. We previously reported that menadione protected a culture of cerebellar granule neurons from death induced by inhibition of complex I of the mitochondrial respiratory chain [11]. Blockade of complex I is probably the main cause of neuronal death induced by EIPA. Moreover, lipid peroxidation may also be involved in the neurodestructive effect of EIPA.
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