Abstract
AbstractIn order to elucidate the mechanism of UV‐induced skin inflammation, the effects of antimalarials, inhibitors of phospholipase A2 and membrane phospholipid methylation, on UV‐induced ear swelling response (ESR) was examined. Antimalarials inhibited ESR induced by 8‐methoxypsoralen (0.5%) plus UVA irradiation (PUVA treatment) or UVB irradiation. However, they did not inhibit ESR induced by the application of arachidonic acid (AA). Although it has been reported that PUVA treatment and UVB irradiation may work through different AA pathways, it seems likely that both PUVA and UVB may affect the initial cellular metabolism of the inflammatory process.
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