Abstract
The relation of sulfhydryl (SH) reactivity to oxygen uptake inhibition by a series of molluscicidal β-nitrostyrene (BNS) derivatives was investigated. Inhibition of O 2 uptake was significantly ( P < 0.05) correlated with SH reactivity of the derivatives studied. Homogenate O 2 uptake inhibition by members of this series was associated with reduced tissue SH content. Preincubation of homogenates with cysteine antagonized the effect of BNS on O 2 uptake. Saturation of the BNS nitroolefinic bond resulted in a product (1-phenyl, 2-nitroethane) with diminished ability to inhibit O 2 uptake as well as reduction of SH reactivity. These data indicated that the effect of the BNS derivative on O 2 uptake was mediated through an interaction between BNS and tissue SH material.
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