Abstract
Previous studies from this laboratory showed that inorganic iodide is oxidized by H2O2 and an enzyme, iodide peroxidase, before it is incorporated into tyrosine and protein by thyroid and salivary homogenates. It is reported here that several other naturally occurring biological oxidants or electron carriers cannot replace H2O2, although it had been shown elsewhere that flavin cofactors stimulate iodide utilization by thyroid preparations. The results of this study demonstrate that catalase or anaerobiosis prevent flavin activation, and thus support the conclusion that the activation is due to the production of H2O2 during autoxidation of the flavin. The peroxidases of salivary and thyroid glands are not identical because a homogenate of salivary gland will oxidize bromide and slightly incorporate it into tyrosine, but thyroid homogenates will not. Neither tissue oxidizes chloride or fluoride. Histidine is iodinated by thyroid and salivary extracts but tyrosine is overwhelmingly iodinated when both amino ...
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
