The Mechanism of Ginkgo Biloba Extract in Treating Glioma

Abstract

<i>Objective: </i>To explore the active components of ginkgo biloba and the possible targets and pathways for treating glioma. <i>Methods</i>: The chemical components and corresponding targets of Ginkgo biloba were searched by TCMSP, and the "component-target" network map was constructed by Cytoscape. The GenCards database, OMIM database and Disgenet database were used to search for glioma-related genes. Ginkgo biloba targets and glioma gene intersections were extracted using R software, and Veen maps were drawn to obtain key targets. PPI network construction and GO and KEGG enrichment analysis were performed by key targets. <i>Results: </i>A total of 27 active ingredients in Ginkgo biloba leaves and 5770 glioma target genes were collected, and 48 key targets were obtained. PPI analysis showed that the core targets were IL6, ESR1, EGFR, PPARG, VEGFA, CYP3A4, AHR, AR, PGR, etc. GO enrichment analysis is mainly concentrated in nuclear receptor activity, neurotransmitter receptor activity, fatty acid metabolic processes, response to foreign stimuli, etc. KEGG enrichment pathways are mainly manifested in: cholinergic synapses, resistance to EGFR tyrosine kinase inhibitors, tumor necrosis factor signaling pathway PI3K-Akt signaling pathway, etc. <i>Conclusion</i>: Ginkgo biloba can treat glioma through multi-target and multi-pathway, which is in line with the characteristics of holistic treatment of diseases in traditional Chinese medicine.