Abstract
Antibodies previously shown to inhibit vectorial proton translocation through cytochrome oxidase vesicles were converted to F(ab′) 2 and Fab′. Neither fragment inhibited proton pumping, although binding capacity was present. However, when a surrogate Fc was added to F(ab′) 2, inhibition of proton translocation was restored; indicating that the inhibition is due to steric hindrance. These results provide insight into mechanisms of energy transduction by oxidase.
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More From: Biochemical and Biophysical Research Communications
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