Abstract
Poly (ADP-ribose) polymerases (PARP) constitute a family of enzymes involved in the regulation of many cellular processes. It plays a vital role in many physical and physiopathological processes.In the past ten years scientists have conducted extensive research on PARP and its inhibitors, among which the role of PARP inhibitors in radiosensitization, chemopotentiation and neuroprotection have been placed close attention. There have been several PARP inhibitors entering the clinical trials, which predicts its sound application perspectives. Key words: Raditolerance; Drug tolerance; Poly(ADP-ribose )polymerase inhibitor
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