Abstract
BackgroundModerate alcohol consumption is associated with a lower risk for coronary heart disease (CHD). A suitably integrated view of the CHD pathogenesis pathway will help to elucidate how moderate alcohol consumption could reduce CHD risk.MethodsA comprehensive literature review was conducted focusing on the pathogenesis of CHD. Biomarker data were further systematically analysed from 294 cohort studies, comprising 1 161 560 subjects. From the above a suitably integrated CHD pathogenetic system for the purpose of this study was developed.ResultsThe resulting integrated system now provides insight into the integrated higher-order interactions underlying CHD and moderate alcohol consumption. A novel ‘connection graph’ further simplifies these interactions by illustrating the relationship between moderate alcohol consumption and the relative risks (RR) attributed to various measureable CHD serological biomarkers. Thus, the possible reasons for the reduced RR for CHD with moderate alcohol consumption become clear at a glance.ConclusionsAn integrated high-level model of CHD, its pathogenesis, biomarkers, and moderate alcohol consumption provides a summary of the evidence that a causal relationship between CHD risk and moderate alcohol consumption may exist. It also shows the importance of each CHD pathway that moderate alcohol consumption influences.
Highlights
Moderate alcohol consumption is associated with a lower risk for coronary heart disease (CHD)
Integrated view of coronary heart disease An investigation of the interconnectivity of lifestyle factors, CHD pathogenesis, and pathophysiological traits attributed with the disorder was conducted
A suitably integrated CHD model of the pathogenesis and serological biomarkers of moderate alcohol consumption was not found in the literature
Summary
Moderate alcohol consumption is associated with a lower risk for coronary heart disease (CHD). A suitably integrated view of the CHD pathogenesis pathway will help to elucidate how moderate alcohol consumption could reduce CHD risk. It is well documented that moderate alcohol (ethanol) consumption is associated with a lower relative risk of CHD events [2,3,4,5,6,7,8,9]. We the purpose of this study is to visually integrate information on how moderate consumption of alcohol influences the pathogenesis of CHD. These influences may provide a useful integrated summary for the plausibility of a causal relationship between moderate alcohol consumption and a reduction in CHD risk
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