Abstract

免疫抑制性寡核苷酸(suppressive oligodeoxynucleotides,Sup ODN)是人工合成的具有特定核苷酸顺序的单链DNA分子.实验证实,富含"TTAGGG"基序的Sup ODN和哺乳动物端粒DNA具有下调Th1型细胞因子及前炎症介质产生的作用[1].我们就其可能对矽尘所致肺泡炎的作用机制和应用进行综述。

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