Abstract
Within cells, formin proteins promote the elongation of cytoskeletal actin filaments by associating with filament tips. This activity has the potential to harness actin-generated pushing forces to change cellular architecture. Mizuno et al. (p. [80][1], published online 9 December; see the Perspective by [Pollard][2] ) have devised a simple method to analyze the movement of single molecules of a member of the formin family, mDia1, along the growing actin filaments; they discovered that formin molecules mechanically rotate on the end of actin filaments, both during growth and depolymerization of the filament, and can thus influence cell shape during important stages in the cell cycle. [1]: /lookup/doi/10.1126/science.1197692 [2]: /lookup/doi/10.1126/science.1200773
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