Abstract
PurposeHidradenitis suppurativa (HS) is a chronic inflammatory skin disease that affects up to 1% of the population in Europe. The EQ-5D is the most commonly used generic instrument for measuring health-related quality of life among HS patients. This study aims to compare the measurement properties of the two adult versions of EQ-5D (EQ-5D-3L and EQ-5D-5L) in patients with HS.MethodsWe recruited 200 consecutive patients with HS (mean age 37 years, 38% severe or very severe HS) to participate in a multicentre cross-sectional survey. Patients completed the EQ-5D-3L, EQ-5D-5L, Dermatology Life Quality Index (DLQI) and Skindex-16 questionnaires.ResultsMore than twice as many different health state profiles occurred in the EQ-5D-5L compared to the EQ-5D-3L (101 vs. 43). A significant reduction in ceiling effect was found for the mobility, self-care and usual activities dimensions. A good agreement was established between the EQ-5D-3L and EQ-5D-5L with an intraclass correlation coefficient of 0.872 (95% CI 0.830–0.903; p < 0.001) that was confirmed by a Bland-Altman plot. EQ-5D-5L improved both the absolute and relative informativity in all dimensions except for anxiety/depression. EQ-5D-3L and EQ-5D-5L demonstrated similar convergent validity with DLQI and Skindex-16. EQ-5D-5L was able to better discriminate between known groups of patients based on the number of comorbidities and disease severity (HS-Physician's Global Assessment).ConclusionIn patients with HS, the EQ-5D-5L outperformed the EQ-5D-3L in feasibility, ceiling effects, informativity and known-groups validity for many important clinical characteristics. We recommend using the EQ-5D-5L in HS patients across various settings, including clinical care, research and economic evaluations.
Highlights
Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent skin disease that usually starts after puberty with painful, deep-seated lesions [1]
This study aimed to compare the measurement performance of two adult versions (3L and 5L) of the EQ-5D questionnaire in a sample of patients diagnosed with HS
We found reduced ceiling effects, improved informativity and better knowngroups validity for many relevant clinical characteristics for the 5L
Summary
Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent skin disease that usually starts after puberty with painful, deep-seated lesions [1]. It typically affects the apocrine gland-bearing areas of the body, most commonly the axillary, inguinal and anogenital regions [2]. Observed comorbidities fall into several categories: cardiovascular diseases, inflammatory and autoimmune diseases, hormone-related disorders and psychiatric illnesses [7, 8]. Therapeutic approaches currently include the use of topical therapies, systemic antibiotics, hormonal therapies, surgical options and biologics, such as adalimumab and infliximab (the latter currently off-label) [2, 9]. Patients often experience a substantial diagnostic delay of up to 7 years that represents a serious burden to both patients and healthcare systems [10,11,12,13]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
