Abstract
1. 1. [ 14C]orotate incorporation into UDP-sugars was used for in-vivo studies of their synthesis. An equation which takes into account the relative molar specific activity (that of UMP = 100) and concentration of the compound newly formed was proposed to calculate the rate of UDP-sugar formation. 2. 2. Approximately a 2-fold and 5-fold lower rate of UDP-glucose synthesis was estimated in guinea-pig and chicken liver, respectively, than in rat liver. The same order in the rate of UDP- N-acetylglucosamine formation was observed. 3. 3. Approximately 50% of UDP-glucose was estimated to enter the UDP-glucuronic acid pathway in guinea-pig liver, while in rat and chicken liver this percentage was considerably lower (12 and 8, respectively). 4. 4. Compared to rat liver, a 20-fold lower rate of UDP-glucose synthesis was calculated in rat small intestine and pancreas. 5. 5. In contrast with rat liver, an equal rate in the synthesis of UDP-glucose and UDP-N-acetylglucosamine was found in rat small intestine and pancreas.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
