Abstract
BackgroundActivation of the platelet plays an important role in the process of atherosclerosis. Mean platelet volume (MPV) is significantly associated with the poor outcome of acute ischemic stroke while the results of studies about the relationship between plateletcrit (PCT) and stroke outcome were inconsistent. The aim of this work is to determine whether an association exists between MPV and plateletcrit (PCT) and outcome of acute ischemic stroke.MethodsWe examined 157 patients with ischemic stroke, admitted to the Sohag University Hospital. The diagnosis of stroke was performed clinically according to The World Health Organization and confirmed by brain CT and MRI when needed. Platelet indices including MPV and PCT were assessed immediately (within 2 h) after admission. After 3 months, the functional outcome was assessed using the modified Rankin Scale (mRS) with assessment of the relationship between platelet indices and stroke outcome.ResultsAbout 50% of the participants have favorable outcome. MPV was significantly higher in the unfavorable group (10.4 ± 2.3 fL) than in the favorable one (8.7 ± 1.3 fL) (P < 0. 001). MPV was an independent predictor of poor short-term outcome of acute stroke after controlling for confounders like diabetes mellitus. The mean PCT was significantly higher in the unfavorable group (0.28 ± 0.1%) than in the favorable one (0.25 ± 0.1%) (P = 0. 04) but not considered as an independent predictor of poor short-term outcome of acute stroke.ConclusionsMPV and PCT were significantly correlated with poor functional outcome, only MPV was an independent predictor of poor short-term outcome of acute stroke after controlling for confounders like DM, and these platelet indices can be used as a prognostic tool.
Highlights
Mean platelet volume (MPV) and PCT were significantly correlated with poor functional outcome, only MPV was an independent predictor of poor short-term outcome of acute stroke after controlling for confounders like DM, and these platelet indices can be used as a prognostic tool
Under some pathological conditions like diabetes mellitus, obesity, metabolic syndrome, acute myocardial infarction (AMI), and stroke, the platelets may be larger in size and more reactive and this phenomenon seems to play an important role in several vascular diseases
These patients were attended for first-ever acute ischemic stroke, which is defined as focal neurological signs or symptoms thought to be of vascular origin that persisted for > 24 h [23] confirmed by brain computed tomography (CT) and/or MRI
Summary
Under some pathological conditions like diabetes mellitus, obesity, metabolic syndrome, acute myocardial infarction (AMI), and stroke, the platelets may be larger in size and more reactive and this phenomenon seems to play an important role in several vascular diseases. Platelet activation plays a key part in the process of atherosclerosis and its potentially major adverse clinical outcomes, such as ischemic stroke and myocardial infarction (MI) [2,3,4]. Mean platelet volume (MPV) is significantly associated with the poor outcome of acute ischemic stroke while the results of studies about the relationship between plateletcrit (PCT) and stroke outcome were inconsistent. The aim of this work is to determine whether an association exists between MPV and plateletcrit (PCT) and outcome of acute ischemic stroke
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