Abstract

Background: Young patients with major depressive disorder are also associated with cognitive deficits. The development of an accurate and effective battery to measure cognitive impairment in young patients with major depressive disorder (Y-MDD) is necessary for both research and clinical practice. This study was designed to test the psychometric properties of the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) in Y-MDD.Method: Fifty Y-MDD patients, 38 euthymic young patients with bipolar disorder (Y-BD), and 51 healthy teenagers were recruited. The MCCB and the Montreal Cognitive Assessment (MoCA) were administered to assess cognitive impairment at baseline. The MCCB was also assessed 2 weeks later in Y-MDD patients. All subjects were between the ages of 13 and 24 years.Result: In the current study, cognitive impairment was greater in Y-BD patients than in Y-MDD patients in some domains. The MCCB has good internal consistency and reliability in Y-MDD patients. The Pearson correlation coefficients for retest reliability were good. Our findings also revealed an acceptable correlation between the MCCB and the MoCA, indicating good concurrent validity of the MCCB. Furthermore, exploratory factor analysis of the MCCB in Y-MDD patients revealed five domains with acceptable internal structures.Conclusion: The MCCB has acceptable psychometric properties and is a sensitive battery of cognitive impairment in Y-MDD patients. In the future, additional studies need to be carried out with larger samples while controlling for the use of psychotropic medications and antidepressants to validate the findings of the present study.

Highlights

  • Cognitive impairment is a consistent feature in patients with major depressive disorder (MDD) and has attracted increasing attention from researchers and in clinical practice [1, 2]

  • There were no significant differences in the duration, the duration of this episode, or the timing of the episodes between the YMDD and young patients with bipolar disorder (Y-BD) groups

  • We found that cognitive impairment was more severe in Y-BD patients than in young patients with major depressive disorder (Y-MDD) patients in some domains

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Summary

Introduction

Cognitive impairment is a consistent feature in patients with major depressive disorder (MDD) and has attracted increasing attention from researchers and in clinical practice [1, 2]. Some current studies have applied systematic batteries of tests to assess cognitive impairment in MDD patients [8,9,10]. Identifying the latent structure of cognition in MDD has important implications for clinical practice and research. The development of an accurate and effective battery to measure cognitive impairment in young patients with major depressive disorder (Y-MDD) is necessary for both research and clinical practice. This study was designed to test the psychometric properties of the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) in Y-MDD

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