Abstract
The purpose . To study structure and to establish associative interaction of pathogenetic links of acute diseases development of bronchopulmonary system in infants. Materials and methods . The examination group consisted of 59 infants (average age 13.8 ± 1.4 months) sick with acute inflammatory bronchopulmonary diseases. Also we tested level of 25-hydroxyvitamin D (25(ОН)D), vitamin D-binding protein, hBPI, cathelicidin LL-37, s1-defensins, lactoferrin in blood serum with help of immunoenzymometric analysis. Selection of prognostically important pathogenetic factors of acute bronchopulmonary disease among infants was conducted using ROC-analysis. The procedure for classifying objects was carried out using Hierarchical Cluster Analysis by method of Centroid-based clustering. Results . Based on results of ROC-analysis were selected 15 potential predictors of development of acute inflammatory diseases of bronchopulmonary system among infants. The analysis made it possible to determine 6 main components . The biggest influence in development of disease was made by the anemia factor, the of inflammation, the maternal factor, the vitamin D supply factor, the immune factor and the phosphorus-calcium exchange factor” with a load of more than 0.6. The performed procedure of hierarchical cluster analysis confirmed initial role of immuno-inflammatory components. The conclusions . The highlighted factors allowed to define a group of parameters, that must be influenced to achieve a maximum effect in carrying out preventive and therapeutic measures. First of all, it is necessary to influence the anemia factor and the calcium exchange factor, as well as the vitamin D supply factor. In other words, to correct vitamin D deficiency and carry out measures aimed at preventing development of anemia. The prevention and treatment of pathological course of pregnancy will help stabilize the maternal factor in future.
Highlights
We tested the level of 25-hydroxyvitamin D (25(ОН)D), vitamin D-binding protein, hBPI, cathelicidin LL-37, ß1-defensins, lactoferrin in blood serum with the help of immunoenzymometric analysis
To correct vitamin D deficiency and carry out measures aimed at preventing the development of anemia
We tested the level of of 25-hydroxyvitamin D (25(ОН) D), vitamin D-binding protein, bactericidal protein that increases the permeability of cells, cathelicidin LL37, ß1-defensins, lactoferrin in blood serum with the help of immunoenzymometric analysis
Summary
The examination group consisted of 59 infants (average age 13.8 ± 1.4 months), of which 46 patients were diagnosed with acute bronchitis and 13 patients – community aguared pneumonia. Selection of prognostically important pathogenetic factors was conducted using ROC-analysis of acute bronchopulmonary disease among infants. In order to determine the least possible number of hidden common factors, that affect the most the occurrence of acute diseases of the bronchopulmonary system in children and their factor loads, a factor analysis was conducted. The basis for modeling for the selection of factor complexes Spearman correlation matrix was chosen with the subsequent determination of the vector load of the indicators that were studied. For exponent sampling with a high factor load on the complex (more than 0,6), the method of orthogonal rotation VARIMAX was used. The procedure of classifying the objects was conduc ted using the Hierarchical Cluster Analysis by the method. The differences were considered meaningful, if р < 0.05 for all kinds of analysis
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