Abstract
The purpose . To study structure and to establish associative interaction of pathogenetic links of acute diseases development of bronchopulmonary system in infants. Materials and methods . The examination group consisted of 59 infants (average age 13.8 ± 1.4 months) sick with acute inflammatory bronchopulmonary diseases. Also we tested level of 25-hydroxyvitamin D (25(ОН)D), vitamin D-binding protein, hBPI, cathelicidin LL-37, s1-defensins, lactoferrin in blood serum with help of immunoenzymometric analysis. Selection of prognostically important pathogenetic factors of acute bronchopulmonary disease among infants was conducted using ROC-analysis. The procedure for classifying objects was carried out using Hierarchical Cluster Analysis by method of Centroid-based clustering. Results . Based on results of ROC-analysis were selected 15 potential predictors of development of acute inflammatory diseases of bronchopulmonary system among infants. The analysis made it possible to determine 6 main components . The biggest influence in development of disease was made by the anemia factor, the of inflammation, the maternal factor, the vitamin D supply factor, the immune factor and the phosphorus-calcium exchange factor” with a load of more than 0.6. The performed procedure of hierarchical cluster analysis confirmed initial role of immuno-inflammatory components. The conclusions . The highlighted factors allowed to define a group of parameters, that must be influenced to achieve a maximum effect in carrying out preventive and therapeutic measures. First of all, it is necessary to influence the anemia factor and the calcium exchange factor, as well as the vitamin D supply factor. In other words, to correct vitamin D deficiency and carry out measures aimed at preventing development of anemia. The prevention and treatment of pathological course of pregnancy will help stabilize the maternal factor in future.
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