The master clock and its timing of hormonal release

Abstract

Event Abstract Back to Event The master clock and its timing of hormonal release Horacio O. De La Iglesia1, 2*, Travis R. Lilley1, Michael D. Schwartz1, Benjamin Smarr1, 2 and Cheryl Wotus3 1 University of Washington, Biology, United States 2 University of Washington, Neurobiology and Behavior, United States 3 Seattle University, Biology, United States The hypothalamic suprachiasmatic nucleus (SCN) contains a master circadian clock that regulates the timing of physiological and behavioral processes. This regulation is achieved through neural and humoral input to other brain centers that directly regulate these processes, as well as through input to extra-SCN and peripheral circadian oscillators that can presumably regulate physiology and behavior locally. The release of hormones is under striking circadian regulation; yet, the pathways by which the SCN times the release of hormones and the specific SCN neurons that are critical for this regulation are not completely clear. We will present data on the regulation of three key endocrine circadian rhythms, the release of melatonin, glucocorticoids and luteinizing hormone in females. To further understand the pathways through which the SCN governs the release of these hormones we exploit the independent oscillation of neuronal oscillators in the forced desynchronized rat and the split hamster, as unique neurologically, genetically and pharmacologically intact animal models. Acknowledgements NIH R01 MH075016 NIH R03 HD061853 NIH PHS NRSA 2T32 GM007270 Keywords: circadian, Glucocorticoids, Luteinizing Hormone, Melatonin, Suprachiasmatic Nucleus Conference: NASCE 2011: The inaugural meeting of the North American Society for Comparative Endocrinology, Ann Arbor, United States, 13 Jul - 16 Jul, 2011. Presentation Type: Invited Symposium Topic: Biological rhythms Citation: De La Iglesia HO, Lilley TR, Schwartz MD, Smarr B and Wotus C (2011). The master clock and its timing of hormonal release. Front. Endocrinol. Conference Abstract: NASCE 2011: The inaugural meeting of the North American Society for Comparative Endocrinology. doi: 10.3389/conf.fendo.2011.04.00123 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Jul 2011; Published Online: 09 Aug 2011. * Correspondence: Dr. Horacio O De La Iglesia, University of Washington, Biology, Seattle, United States, horaciod@uw.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Horacio O De La Iglesia Travis R Lilley Michael D Schwartz Benjamin Smarr Cheryl Wotus Google Horacio O De La Iglesia Travis R Lilley Michael D Schwartz Benjamin Smarr Cheryl Wotus Google Scholar Horacio O De La Iglesia Travis R Lilley Michael D Schwartz Benjamin Smarr Cheryl Wotus PubMed Horacio O De La Iglesia Travis R Lilley Michael D Schwartz Benjamin Smarr Cheryl Wotus Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.