Abstract
A decade has already passed since we discovered, essentially by serendipity, the membranal glycoprotein later named MAst cell Function-associated Antigen (MAFA). While trying to identify the still elusive Ca2+ channel responding to the type 1 Fcɛ receptor (FcɛRI) stimulus, a series of monoclonal antibodies (mAb) were raised to the rat mucosal-type mast cells of the RBL-2H3 line. One of these mAbs, G63, caused a dose-dependent inhibition of the secretory response to the FcɛRI stimulus and was shown to bind to a membranal protein which we proceeded to isolate and characterize (Ortega-Soto and Pecht 1988).KeywordsMast CellFluorescence Resonance Energy TransferSecretory ResponseCytosolic TailHuman Lung Mast CellThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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