Abstract
Locally advanced rectal cancer is currently treated with preoperative radiochemotherapy, but the response is not uniform. Most patients benefit from preoperative CRT, however, a small proportion of a patient population is less likely to respond to the treatment. The purpose of this study was to measure neoadjuvant therapy combined with Ki-67 and VEGF expression in pretreatment biopsies and postoperative specimens，serum carcinoembryonic antigen (CEA) and CA19-9 level from patients with locally advanced rectal cancer receiving intensive neoadjuvant treatment and to correlate the findings with clinical outcome.Â
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