Abstract
Introduction. The MANGUA cohort is an ongoing multicenter, observational study of people living with HIV/AIDS in Guatemala. The cohort is based on the MANGUA application which is an electronic database to capture essential data from the medical records of HIV patients in care. Methods. The cohort enrolls HIV-positive adults ≥16 years of age. A predefined set of sociodemographic, behavioral, clinical, and laboratory data are registered at entry to the cohort study. Results. As of October 1st, 2012, 21 697 patients had been included in the MANGUA cohort (median age: 33 years, 40.3% female). At enrollment 74.1% had signs of advanced HIV infection and only 56.3% had baseline CD4 cell counts. In the first 12 months after starting antiretroviral treatment 26.9% (n = 3938) of the patients were lost to the program. Conclusions. The implementation of a cohort of HIV-positive patients in care in Guatemala is feasible and has provided national HIV indicators to monitor and evaluate the HIV epidemic. The identified percentages of late presenters and high rates of LTFU will help the Ministry to target their current efforts in improving access to diagnosis and care.
Highlights
The MANGUA cohort is an ongoing multicenter, observational study of people living with HIV/AIDS in Guatemala
As of October 1st, 2012, 21 697 patients had been included in the MANGUA cohort
Percentages of patients with available data on the following variables are as follows: transmission route (58%), combination antiretroviral therapy (cART) status at enrollment (41.1%), advanced HIV status at enrollment (50.2%), and CD4 cell counts at enrollment (56.3%)
Summary
The MANGUA cohort is an ongoing multicenter, observational study of people living with HIV/AIDS in Guatemala. The cohort is based on the MANGUA application which is an electronic database to capture essential data from the medical records of HIV patients in care. The cohort enrolls HIV-positive adults ≥16 years of age. The implementation of a cohort of HIV-positive patients in care in Guatemala is feasible and has provided national HIV indicators to monitor and evaluate the HIV epidemic. MANGUA study code, date of enrollment, gender, date of birth, country of origin, province of residence, ethnicity, religion, marital status, educational level, employment status, name of UAI, previous treatment, casualty date, casualty cause, cause of death, informed consent signed, vulnerability group, transmission group, probable year of infection, sexual orientation, and condom use.
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