Abstract

Hyponatremia is reported to be the most common electrolyte abnormality encountered in clinical prac- tice. Diagnosis and principles of management of hy- ponatremia are everyday issues in patient care. Inter- est has also been generated by its association with adverse prognosis from studies in specific disease groups. Patients with human immunodeficiency virus (HIV) disease are living longer and medical diseases similar to the general population are more frequently encountered in them. Hyponatremia has been ob- served to be widely prevalent in both hospitalized and outpatient HIV patients, although population-based estimates are not known. From case series, these pa- tients appear to be at greater risk for the development of hyponatremia from pathomechanisms encountered in the non-HIV population. In addition, certain HIV- specific mechanisms from infectious etiologies, endo- crine causes, and medications are unique to them. Us- ing an illustrative case as an example, in the following review, we discuss the varied etiologies, pathogenetic mechanisms , clinical features, diagnosis, and outline the management of hyponatremia in HIV patients.

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