Abstract
Asthma is a complex and heterogenous disease characterized by variability in disease expression and severity. Multiple extrapulmonary comorbidities and treatable traits are common in people with asthma, and there is an increasing appreciation of how these may complicate asthma management. This review will discuss the prevalence and impact of extrapulmonary comorbidities/risk factors or “traits,” which have been found to co-exist in asthma (obesity, symptoms of depression and/or anxiety and physical inactivity), the impact these traits have on future outcomes (including exacerbation risk and quality of life) and asthma management, and how we should target treatment in asthma when these extrapulmonary traits are present.
Highlights
Despite the significant advances in asthma treatment that have been achieved over the past 30 years, improvements in asthma outcomes have stalled, and the burden of asthma from a patient [1], healthcare and economic [2, 3] perspective remains substantial
There is an increasing appreciation of the impact extrapulmonary traits have on asthma outcomes and the asthma management challenges that may arise when these traits are present
There is promising evidence that managing these traits improves important clinical outcomes in asthma, reinforcing the importance of individualized asthma management strategies that look beyond the pulmonary system
Summary
Citation: McLoughlin RF and McDonald VM (2021) The Management of Extrapulmonary Comorbidities and Treatable Traits; Obesity, Physical Inactivity, Anxiety, and Depression, in Adults With Asthma. Front. Allergy 2:735030. doi: 10.3389/falgy.2021.735030 Asthma is a complex and heterogenous disease characterized by variability in disease expression and severity. Multiple extrapulmonary comorbidities and treatable traits are common in people with asthma, and there is an increasing appreciation of how these may complicate asthma management. This review will discuss the prevalence and impact of extrapulmonary comorbidities/risk factors or “traits,” which have been found to co-exist in asthma (obesity, symptoms of depression and/or anxiety and physical inactivity), the impact these traits have on future outcomes (including exacerbation risk and quality of life) and asthma management, and how we should target treatment in asthma when these extrapulmonary traits are present. Keywords: asthma, obesity, physical inactivity, anxiety, depression, treatable traits, extrapulmonary
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