Abstract
Immediate phase (minutes) There is an acute increase in systemic arterial pressure (SAP), a smaller increase in intracranial pressure (ICP), apnoea, and an isoelectric EEG. z The SAP increases because of hypothalamic discharge; ICP because autoregulation of cerebral blood flow (CBF) is exceeded, and because there is widespread intracranial vascular spasm. The latter in due to microvascular haemorrhage and reflex vessel responses to shearing forces. After about a minute all these disturbances abate, perhaps in part due to mobilization of endogenous opioids. 3
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Schedule a callMore From: Canadian journal of anaesthesia = Journal canadien d'anesthesie
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