Abstract
As cardio metabolic disease manifestations tend to cluster in families there is a need to better understand the underlying mechanisms in order to further develop preventive strategies. In fact, genetic markers used in genetic risk scores, important as they are, will not be able alone to explain these family clusters. Therefore, the search goes on for the so called missing heritability to better explain these associations. Shared lifestyle and social conditions in families, but also early life influences may be of importance. Gene-environmental interactions should be explored. In recent years interest has grown for the role of diet-microbiota associations, as microbiota patterns may be shared by family members. In the Malmö Offspring Study that started in 2013, we have so far been able to examine about 4700 subjects (18–71 years) representing children and grandchildren of index subjects from the first generation, examined in the Malmö Diet Cancer Study during 1991 to 1996. This will provide rich data and opportunities to analyse family traits of chronic disease across three generations. We will provide extensive genotyping and phenotyping including cardiovascular and respiratory function, as well as markers of glucose metabolism. In addition, also cognitive function will be assessed. A 4-day online dietary recall will be conducted and gut as well as oral microbiota analysed. The ambition is to provide one of the first large-scale European family studies with individual data across three generations, which could deepen our knowledge about the role of family traits for chronic disease and its underlying mechanisms.
Highlights
The Global Burden of Disease (GBD) project reports noncommunicable cardio metabolic conditions and diseases, such as obesity, type 2 diabetes (T2D), and cardiovascular disease (CVD), together with cancer, to continue to increaseElectronic supplementary material The online version of this article contains supplementary material, which is available to authorized users.Jan Waldenströms gata 15, 5th floor, 20502 Malmö, Sweden 4 Department of Cardiology, Skane University Hospital, Malmö, Sweden world-wide, providing enormous demands on future healthcare systems [1]
Interim analysis In May 2017, the Malmö Offspring Study (MOS) study had reach halftime according to initial recruitment goals, with a participation rate of 47.0% and an age span of 18–71 years
We collect a wide range of data including somatic phenotyping, lifestyle characteristics and dietary profiling, as well as collection of faecal and oral samples for microbiome analysis
Summary
Jan Waldenströms gata 15, 5th floor, 20502 Malmö, Sweden 4 Department of Cardiology, Skane University Hospital, Malmö, Sweden world-wide, providing enormous demands on future healthcare systems [1] These conditions have previously been described as diseases of wealth, but today their prevalence is increasing more rapidly than wealth around the world. Among the greatest challenges of medical sciences is to find novel and more effective ways to prevent and treat these diseases. For this purpose, it is important that large population- and family-based cohorts of individuals exposed to present-day environmental factors are collected and investigated.
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