Abstract
B identifies a system of two or more loci which have major effects on hostversus-graft and graft-versus-host reactions. LikeH-2 andHL-A, B encodes lymphocyte antigens which react with alloantibodies and allogenic lymphocytes. Like the mammalian MHCs,B has many alleleic variants. LikeH-2 alleles, some of these are associated with specific differences in immune competence and susceptibility to viral oncogenesis. UnlikeH-2, there is no evidence thatB histocompatibility andB serology represent separable genetic systems. In addition,B is associated with functional differences unknown in mammals. These include a general difference in immune competence and differences in the frequency of herpesvirus lymphoma and in reproductive and general fitness. We conclude that the different kinds of information available forB and the mammalian MHCs reflect differences in circumstance, sampling, and technique, and should be regarded as less fundamental than the immunogenetic similarities. We suggest thatB is the phylogenetic homologue ofH-2 andHL-A.
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