Abstract

The influence of social relationships extends beyond emotional well-being to influence long-term physical-health outcomes, including mortality risk. Despite the varied measurement approaches used to examine social relationships within the health literature, the data can be synthesized using social connection as an organizing framework. This review discusses cumulative scientific evidence of links between various aspects of social connection and mortality, as well as supporting evidence for links with morbidity and plausible mechanisms. This evidence fulfills the criteria outlined in the Bradford Hill guidelines for establishing causality. Despite strong evidence currently available, several gaps remain and will need to be addressed if society is to rise to the challenge of developing effective interventions to reduce risk associated with social disconnection. This evidence has important broader implications for medical practice and public health.

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