Abstract
The article presents information about the protein responsible for the iron depot in the body – ferritin. Its physiological role and clinical significance are demonstrated. A batophenanthroline method was used to determine the range of iron in the blood serum and the range of the total iron-binding capacity of the blood serum. The range of unsaturated iron-binding capacity of blood serum was calculated as the difference between total iron-binding capacity in blood serum and the range of iron in blood serum. The transferrin saturation coefficient of iron was defined as the ratio of the content of iron in blood serum to the total iron-binding capacity in blood serum. The range of transferrin was determined by the rate of the total iron-binding capacity in blood serum, and ferritin using the radiometric method. The dynamics of changes in ferritin content in malignant neoplasm anemia in patients with bladder cancer has been demonstrated. The conclusion about the importance of this parameter for laboratory diagnosis of iron deficiency and anemia of malignant neoplasms is made.
Highlights
Bladder cancer is one of the ten most common diseases of the urinary system of non-plastic nature, and given its prevalence, it is second only to prostate cancer (Titov, 2018)
We found that patients of groups II and III had a significantly lower range of iron-binding capacity in blood serum, which reflects the presence of iron metabolism disorders (p
We found that patients of groups II and III, had a significantly lower range of saturation of transferrin with iron, which confirms the presence of iron metabolism disorders (p
Summary
Bladder cancer is one of the ten most common diseases of the urinary system of non-plastic nature, and given its prevalence, it is second only to prostate cancer (Titov, 2018). Among the entire population of Ukraine, the incidence range of malignant neoplasms of the bladder in the years 2012-2018 ranged from 9,7 to 11,4 per 100 thousand population. Among the male population of Ukraine, this range was significantly higher and ranged from 17,1 to 19,8 per 100 thousand population (Linchevskii, 2019). Urotelial bladder cancer is the most common non-plastic form of this organ and in percentage terms reaches almost 90%. In three-quarters of cases, urotelial bladder cancer is detected in stages Ta and T1 (non-invasive stages), but as clinicians note, the results of treatment in non-invasive stages do not always give the expected outcome. Recommendations of the European Society of Oncologists (2018) for the management of patients with malignant neoplasm anemia have been developed
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