Abstract
To analysis the main component of Laetiporus sulphureus primary separation product (LSPSP) and observe the hepatoprotective effect of LSPSP. Silica column and HPLC was adopted to isolate main constituents from LSPSP. The main components were analyzed and identified by HPLC and HNMR. And then its hepatoprotective effect was evaluated, we used Sprague-Dawley rats as experimental rats, and made hepatic fibrosis models induced by carbon tetrachloride (CCl4).The hepatoprotective effects of SPSP on hepatic fibrosis of rats were evaluated by content of AST and ALT, levels of liver cell injury and degree of liver fibrosis. In the study, we found that LSPSP mainly contains eburicoic acid and trametenolic acid B. After treatment with LSPSP, the levels of serum AST and ALT significantly decreased, alleviated liver cell damage, reduced the collagen deposition in the liver tissue, and then inhibited liver fibrosis. Our studies indicated that LSPSP main components areeburicoic acid and trametenolic acid B, it exerted beneficially hepatoprotective effects on the CCl4 induced hepatic fibrosis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
